![]() ![]() Amara SG, Jonas V, Rosenfeld MG, Ong ES, Evans RM.A possible involvement of cyclic AMP in the expression of desensitization of the nicotinic acetylcholine receptor. Albuquerque EX, Deshpande SS, Aracava Y, Alkondon M, Daly JW.Links to PubMed are also available for Selected References. Get a printable copy (PDF file) of the complete article (1.2M), or click on a page image below to browse page by page. Full textįull text is available as a scanned copy of the original print version. Furthermore, CGRP might be implicated in other trophic actions mediated by cAMP in skeletal muscle cells. The present findings suggest that cAMP is one of the second messengers which mediate the increase in acetylcholine receptor number elicited by CGRP. Nanomolar concentrations of CGRP elicit significant increases in both cellular cAMP levels and acetylcholine receptor numbers. This effect is, at least in part, mediated by an increase in cAMP synthesis, as the peptide also activates adenylate cyclase in chick muscle membranes. In a search for the second messengers involved, we now demonstrate that CGRP stimulates accumulation of cyclic AMP (cAMP) in cultured chick myotubes. CGRP might thus serve as one of the signals by which motoneurons regulate endplate development. Moreover, CGRP causes an increase in the number of acetylcholine receptors on the surface of cultured chick myotubes. Recent immunocytochemical studies have shown that calcitonin gene-related peptide (CGRP) coexists with the neurotransmitter acetylcholine in spinal motoneurons of the chick. ![]()
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